![]() ![]() Before the VQ Mismatch, There Was a VQ Matchįor normal gas exchange to occur, oxygen within the lungs has to move into the bloodstream and carbon dioxide within the bloodstream has to move into the lungs. The difference in pathophysiology between a shunt and dead space is essentially why oxygen therapy works wonders in some patients but has a minimal effect on others. But how hypoxemia reacts to oxygen therapy is different based on whether the patient has a shunt or dead space the two problems associated with a VQ mismatch. The management for hypoxemia seems easy enough provide oxygen therapy as quick band-aid therapy to counteract the problem. V D-Alv was higher in infants that have undergone prolonged mechanical ventilation.Īnatomical dead space capnography newborn infants physiological dead space premature.Hypoxemia is an abnormally low concentration of oxygen in the blood which can lead to dire consequences when left untreated. V D-Ana /kg and V D-Alv /kg increased with decreasing weight and gestation. The median V D-Alv /kg was not higher in prematurely born infants compared to term infants after adjusting for differences in respiratory rate and days of ventilation (P = 0.482). The median V D-Ana /kg was higher in prematurely born infants compared to term infants. V D-Ana and V D-Alv were related to body weight at the time of study. V D-Alv was determined by subtracting V D-Ana from the physiological dead space which was determined by the Bohr-Enghoff equation. V D-Ana was determined using Fowler's method of volumetric capnography. Retrospective analysis of data collected at King's College Hospital NHS Foundation Trust, London, UK.įifty-six infants (11 term, 45 preterm) were studied at a median age of 8 (IQR 2-33) days. V D-Ana and V D-Alv will be higher in prematurely born compared to term born infants. ![]() To compare the anatomical (V D-Ana ) and alveolar dead space (V D-Alv ) in term and prematurely born infants and identify the clinical determinants of those indices. ![]()
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